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MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES
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DeCS
Descriptor
English
:
Mannose-Binding Protein-Associated Serine Proteases
Descriptor
Spanish
:
Serina Proteasas Asociadas a la Proteína de Unión a la Manosa
Descriptor
Portuguese
:
Serina Proteases Associadas a Proteína de Ligação a Manose
Tree Number:
D08.811.277.656.300.760.501
D12.776.124.486.274.045.387.875
Definition
English
:
Serum
serine
proteases which participate in
COMPLEMENT ACTIVATION
. They are activated when complexed with the
MANNOSE-BINDING LECTIN
, therefore also known as
Mannose-binding protein-Associated Serine Proteases
(MASPs). They cleave
COMPLEMENT C4
and
COMPLEMENT C2
to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.
Indexing Annotation
English
:
see SCR for organism-specific terms
Pharmacological Action:
Immunologic Factors
History Note
English
:
2006 (1994)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
50582
Unique Identifier:
D050606
Occurrence in VHL
:
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