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NORDIHYDROGUAIARETIC ACID
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DeCS
Descriptor
English
:
Nordihydroguaiaretic Acid
Descriptor
Spanish
:
Ácido Nordihidroguaiarético
Descriptor
Portuguese
:
Ácido Nordiidroguaiarético
Tree Number:
D02.455.426.559.389.140.450.582
D02.755.166.550
Definition
English
:
A potent
lipoxygenase
inhibitor that interferes with
arachidonic acid
metabolism
. The compound also inhibits formyltetrahydrofolate synthetase,
carboxylesterase
, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in
fats
and
oils.
Indexing Annotation
English
:
DF: NDGA
Pharmacological Action:
Antioxidants
Cyclooxygenase Inhibitors
Lipoxygenase Inhibitors
History Note
English
:
91(87); was see under CATECHOLS 1987-90
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
19266
Unique Identifier:
D009637
Occurrence in VHL
:
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