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PHLEOMYCINS
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DeCS
Descriptor
English
:
Phleomycins
Descriptor
Spanish
:
Fleomicinas
Descriptor
Portuguese
:
Fleomicinas
Tree Number:
D09.400.420.110.710
D12.644.233.110.710
Definition
English
:
Water-soluble, copper-containing low
molecular weight
polypeptides obtained from the
culture
medium of
Streptomyces
verticillus. They are specific inhibitors of
DNA
synthesis in
bacteria
and have been found to act as antitumor agents. They have also been used against rust
fungi
of
plants.
Pharmacological Action:
Antibiotics, Antineoplastic
Nucleic Acid Synthesis Inhibitors
History Note
English
:
91(81); was see under BLEOMYCINS 1981-90; was PHLEOMYCIN see under ANTIBIOTICS 1975-80
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
10886
Unique Identifier:
D010692
Occurrence in VHL
:
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