Search on: PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE 
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Descriptor English:   Phosphatidylinositol 4,5-Diphosphate 
Descriptor Spanish:   Fosfatidilinositol 4,5-Difosfato 
Descriptor Portuguese:   Fosfatidilinositol 4,5-Difosfato 
Synonyms English:   Phosphatidylinositol-4,5-Bisphosphate
PIP2
PtdInsP2  
Tree Number:   D10.570.755.375.760.400.942.625.900
Definition English:   A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994) 
Indexing Annotation English:   DF: note short X refs
History Note English:   97; see PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE (NM) 1981-96 
Allowable Qualifiers English:  
analogs & derivatives administration & dosage
adverse effects agonists
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use urine
Record Number:   33029 
Unique Identifier:   D019269 

Occurrence in VHL:
 

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