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PLATELET GLYCOPROTEIN GPIB-IX COMPLEX
Descriptors Found:
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DeCS
Descriptor
English
:
Platelet Glycoprotein GPIb-IX Complex
Descriptor
Spanish
:
Complejo GPIb-IX de Glicoproteína Plaquetaria
Descriptor
Portuguese
:
Complexo Glicoproteico GPIb-IX de Plaquetas
Synonyms
English
:
Antigens, CD42a
Antigens, CD42b
Antigens, CD42c
Antigens, CD42d
CD42a Antigens
CD42b Antigens
CD42c Antigens
CD42d Antigens
Platelet Membrane Glycoprotein Ib
Platelet Membrane Glycoprotein IX
Platelet Membrane Glycoprotein V
Tree Number:
D12.776.395.550.625.460
D12.776.395.550.625.800.780
D12.776.543.550.625.460
D12.776.543.550.625.800.780
D12.776.543.750.705.675.568
Definition
English
:
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for
von Willebrand factor
and for
thrombin
. Congenital deficiency of the GPIb-IX complex results in
Bernard-Soulier syndrome
. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in
Bernard-Soulier syndrome.
Indexing Annotation
English
:
important in platelet aggreg; note X refs as CD42
antigens
; DF: GPIB IX
Entry Combination - descr/qualif
English
:
Platelet Glycoprotein GPIb-IX Complex
/
deficiency
use
Bernard-Soulier Syndrome
History Note
English
:
96; PLATELET MEMBRANE GLYCOPROTEIN IB was see PLATELET MEMBRANE GLYCOPROTEINS 1987-95
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
32648
Unique Identifier:
D019038
Occurrence in VHL
:
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