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PROINSULIN C-PEPTIDE
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DeCS
Descriptor
English
:
C-Peptide
Descriptor
Spanish
:
Péptido C
Descriptor
Portuguese
:
Peptídeo C
Synonyms
English
:
Proinsulin C-Peptide
Tree Number:
D06.472.699.587.740.250
D12.644.548.586.740.250
Definition
English
:
The middle segment of
proinsulin
that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of
proinsulin
, equimolar
INSULIN
and
C-peptide
are released.
C-peptide
immunoassay
has been used to assess pancreatic beta cell function in diabetic
patients
with circulating
insulin antibodies
or exogenous
insulin
.
Half-life
of
C-peptide
is 30 min, almost 8 times that of
insulin.
Indexing Annotation
English
:
from
proinsulin
only: not for
peptide fragments
from other
proteins
( = PEPTIDE FRAGMENTS)
History Note
English
:
84(77); was see under PEPTIDES 1977-83
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
2130
Unique Identifier:
D002096
Occurrence in VHL
:
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