Search on: PROTEIN INHIBITORS OF ACTIVATED STAT 
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Descriptor English:   Protein Inhibitors of Activated STAT 
Descriptor Spanish:   Proteínas Inhibidoras de STAT Activados 
Descriptor Portuguese:   Proteínas Inibidoras de STAT Ativados 
Synonyms English:   PIAS1 Protein Inhibitor of Activated STAT  
Tree Number:   D12.644.360.024.311
D12.776.157.057.124
D12.776.476.024.405
Definition English:   A family of structurally related proteins that are constitutively expressed and that negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. PIAS proteins inhibit the activity of SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION. 
History Note English:   2006(1998) 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
drug effects deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use ultrastructure
urine  
Record Number:   50781 
Unique Identifier:   D050828 

Occurrence in VHL:
 

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