Search on: PROTEIN KINASE C-ALPHA 
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Descriptor English:   Protein Kinase C-alpha 
Descriptor Spanish:   Proteína Quinasa C-alfa 
Descriptor Portuguese:   Proteína Quinase C-alfa 
Synonyms English:   PKC-alpha Serine-Threonine Kinase  
Tree Number:   D08.811.913.696.620.682.700.725.100
Definition English:   A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells. 
History Note English:   2006(1999) 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   50721 
Unique Identifier:   D051571 

Occurrence in VHL: 		 

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