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DeCS
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Descriptor English:
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Calcineurin
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Descriptor Spanish:
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Calcineurina
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Descriptor Portuguese:
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Calcineurina
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Synonyms English:
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Calcineurin A
Calcineurin B
Protein Phosphatase-2B
PP2B
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Tree Number:
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D08.811.277.352.650.625.150
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Definition English:
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A calcium- and calmodulin-binding protein present in highest concentrations in the central nervous system. Calcineurin is composed of two subunits. A catalytic subunit, calcineurin A, and a regulatory subunit, calcineurin B, with molecular weights of about 60 kDa and 19 kDa, respectively. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including histones, myosin light chain, and the regulatory subunit of cAMP-dependent protein kinase. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes in T-lymphocytes that act by inhibiting T-cell activation. |
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Indexing Annotation English:
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a calcium- & calmodulin-binding protein in the CNS; DF: note short X ref
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History Note English:
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98; see CALCINEURIN (NM) 1987-97
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Allowable Qualifiers English:
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Record Number:
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33429
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Unique Identifier:
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D019703
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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