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PROTEIN S DEFICIENCY
Descriptors Found:
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DeCS
Descriptor
English
:
Protein S Deficiency
Descriptor
Spanish
:
Deficiencia de Proteína S
Descriptor
Portuguese
:
Deficiência de Proteína S
Tree Number:
C15.378.100.800
C15.378.147.890
C15.378.925.800
Definition
English
:
An autosomal dominant disorder showing decreased levels of
plasma
protein S
antigen or activity, associated with
venous thrombosis
and
pulmonary embolism
.
PROTEIN S
is a vitamin K-dependent
plasma
protein that inhibits
blood
clotting by serving as a cofactor for activated
PROTEIN C
(also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of
protein C deficiency
. Treatment with
heparin
for acute thrombotic processes is usually followed by
maintenance
administration of coumarin drugs for the prevention of recurrent
thrombosis
. (From Harrison's Principles of
Internal Medicine
, 12th ed, p1511; Wintrobe's Clinical
Hematology
, 9th ed, p1523)
Indexing Annotation
English
:
a
blood
protein disord causing thromboses; DF:
PROTEIN S
DEFIC
History Note
English
:
95
Allowable Qualifiers
English
:
blood
cerebrospinal fluid
chemically induced
classification
congenital
complications
diet therapy
diagnosis
drug therapy
economics
ethnology
embryology
enzymology
epidemiology
etiology
genetics
history
immunology
metabolism
microbiology
mortality
nursing
pathology
prevention & control
physiopathology
parasitology
psychology
radiography
rehabilitation
radionuclide imaging
radiotherapy
surgery
therapy
urine
ultrasonography
veterinary
virology
Record Number:
32063
Unique Identifier:
D018455
Occurrence in VHL
:
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