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DeCS
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Descriptor English:
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Proto-Oncogene Proteins c-abl
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Descriptor Spanish:
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Proteínas Proto-Oncogénicas c-abl
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Descriptor Portuguese:
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Proteínas Proto-Oncogênicas c-abl
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Synonyms English:
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c-abl Proteins
abl Proto-Oncogene Proteins
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Tree Number:
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D08.811.913.696.620.682.725.500
D12.776.624.664.700.167
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Definition English:
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Non-receptor tyrosine kinases encoded by the c-abl gene. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation. |
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See Related English:
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Fusion Proteins, bcr-abl
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History Note English:
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91
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Allowable Qualifiers English:
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Record Number:
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29092
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Unique Identifier:
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D016315
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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