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PROTO-ONCOGENE PROTEINS C-BCR
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DeCS
Descriptor
English
:
Proto-Oncogene Proteins c-bcr
Descriptor
Spanish
:
Proteínas Proto-Oncogénicas c-bcr
Descriptor
Portuguese
:
Proteínas Proto-Oncogênicas c-bcr
Synonyms
English
:
bcr Proto-Oncogene Proteins
c-bcr Proteins
Tree Number:
D08.811.913.696.620.682.700.759
D12.776.624.664.700.171
Definition
English
:
Proto-oncogene protein bcr is a serine-threonine kinase that functions as a negative regulator of
CELL PROLIFERATION
and NEOPLASTIC CELL TRANSFORMATION. It is commonly fused with cellular abl protein to form BCR-ABL FUSION
PROTEINS
in
PHILADELPHIA CHROMOSOME
positive
LEUKEMIA
patients.
History Note
English
:
2006(1988)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
50725
Unique Identifier:
D051562
Occurrence in VHL
:
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