Search on: RECEPTORS, DEATH DOMAIN 
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Descriptor English:   Receptors, Death Domain 
Descriptor Spanish:   Receptores de Muerte Celular 
Descriptor Portuguese:   Receptores de Morte Celular 
Synonyms English:   Death Domain Receptors  
Tree Number:   D12.776.543.750.073
Definition English:   A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. 
See Related English:   Receptors, Tumor Necrosis Factor
 
History Note English:   2007 
Allowable Qualifiers English:  
administration & dosage agonists
antagonists & inhibitors analysis
biosynthesis blood
chemistry classification
drug effects deficiency
genetics history
immunology isolation & purification
metabolism physiology
radiation effects therapeutic use
ultrastructure  
Record Number:   52336 
Unique Identifier:   D053218 

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