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RECEPTORS, THROMBIN
Descriptors Found:
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DeCS
Descriptor
English
:
Receptors, Thrombin
Descriptor
Spanish
:
Receptores de Trombina
Descriptor
Portuguese
:
Receptores da Trombina
Synonyms
English
:
Thrombin Receptors
Tree Number:
D12.776.395.550.625.800
D12.776.543.550.625.800
D12.776.543.750.100.875
D12.776.543.750.750.850
D12.776.543.750.792.500
Definition
English
:
A
family
of proteinase-activated receptors that are specific for
THROMBIN
. They are found primarily on PLATELETS and on
ENDOTHELIAL CELLS
. Activation of
thrombin
receptors occurs through the proteolytic action of
THROMBIN
, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through
HETEROTRIMERIC GTP-BINDING PROTEINS
. Small synthetic
peptides
that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
Indexing Annotation
English
:
DF: RECEPT
THROMBIN
History Note
English
:
1994; use THROMBIN RECEPTOR (NM) 1981-1993; for TRAP PEPTIDE use RECEPTORS, THROMBIN (NM) 2000-2003
Allowable Qualifiers
English
:
administration & dosage
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
chemistry
classification
drug effects
deficiency
genetics
history
immunology
isolation & purification
metabolism
physiology
radiation effects
therapeutic use
ultrastructure
Record Number:
31095
Unique Identifier:
D018179
Occurrence in VHL
:
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