Search on: RETINOBLASTOMA PROTEIN 
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Descriptor English:   Retinoblastoma Protein 
Descriptor Spanish:   Proteína de Retinoblastoma 
Descriptor Portuguese:   Proteína do Retinoblastoma 
Synonyms English:   p105-Rb Protein
Rb Protein
Retinoblastoma Nuclear Phosphoprotein p105-Rb  
Tree Number:   D12.776.260.704
D12.776.624.776.745
D12.776.660.807
D12.776.744.770
Definition English:   Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein. 
Indexing Annotation English:   /biosyn /drug eff /physiol /ultrastruct permitted
History Note English:   91 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
drug effects deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use ultrastructure
urine  
Record Number:   29109 
Unique Identifier:   D016160 

Occurrence in VHL:
 

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