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RYANODINE
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DeCS
Descriptor
English
:
Ryanodine
Descriptor
Spanish
:
Rianodina
Descriptor
Portuguese
:
Rianodina
Tree Number:
D02.455.849.291.686
D03.132.740
D03.383.129.578.805
Definition
English
:
A methylpyrrole-carboxylate from
RYANIA
that disrupts the
RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL
to modify
CALCIUM
release from
SARCOPLASMIC RETICULUM
resulting in alteration of
MUSCLE CONTRACTION
. It was previously used in
INSECTICIDES
. It is used experimentally in conjunction with
THAPSIGARGIN
and other inhibitors of
CALCIUM
ATPASE uptake of
calcium
into
SARCOPLASMIC RETICULUM.
History Note
English
:
91(75); was see under ALKALOIDS 1975-90
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
12805
Unique Identifier:
D012433
Occurrence in VHL
:
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