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STEROID 11-BETA-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 11-beta-Hydroxylase
Descriptor
Spanish
:
Esteroide 11-beta-Hidroxilasa
Descriptor
Portuguese
:
Esteróide 11-beta-Hidroxilase
Synonyms
English
:
CYP11B1
Cytochrome P-450 CYP11B1
Cytochrome P-450(11 beta)
Steroid 11-beta-Monooxygenase
Tree Number:
D08.244.453.915.750
D08.811.682.690.708.170.915.750
D08.811.682.690.708.783.750
D12.776.422.220.453.915.750
Definition
English
:
A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of
steroids
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of
CORTICOSTERONE
and
HYDROCORTISONE
. Defects in CYP11B1 cause congenital adrenal
hyperplasia
(ADRENAL
HYPERPLASIA
, CONGENITAL).
Entry Combination - descr/qualif
English
:
Steroid 11-beta-Hydroxylase
/
deficiency
use
Adrenal Hyperplasia, Congenital
See Related
English
:
Adrenal Hyperplasia, Congenital
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
23463
Unique Identifier:
D013252
Occurrence in VHL
:
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