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TGF-BETA1
Descriptors Found:
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DeCS
Descriptor
English
:
Transforming Growth Factor beta1
Descriptor
Spanish
:
Factor Transformador de Crecimiento beta1
Descriptor
Portuguese
:
Fator Transformador de Crescimento beta1
Synonyms
English
:
TGF-beta1
Tree Number:
D12.644.276.374.687.100
D12.644.276.960.720.100
D12.776.467.374.687.100
D12.776.467.960.720.100
D23.529.374.687.100
D23.529.960.720.100
Definition
English
:
A subtype of
transforming growth factor beta
that is synthesized by a wide variety of
cells
. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The
association
of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of
CAMURATI-ENGELMANN SYNDROME.
Entry Combination - descr/qualif
English
:
Transforming Growth Factor beta1
/
deficiency
use
Camurati-Engelmann Syndrome
History Note
English
:
2007(1992)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
52285
Unique Identifier:
D053773
Occurrence in VHL
:
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