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DeCS
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Descriptor English:
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Transient Receptor Potential Channels
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Descriptor Spanish:
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Canales TRP
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Descriptor Portuguese:
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Canais de Receptores Transientes de Potencial
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Synonyms English:
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TRP Cation Channels
TRP Membrane Proteins
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Tree Number:
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D12.776.157.530.400.901
D12.776.543.585.400.901
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Definition English:
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A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES. |
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Indexing Annotation English:
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note entry terms: TRP refers to transient receptor potential not TRYPTOPHAN
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History Note English:
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2006
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Allowable Qualifiers English:
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Record Number:
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50884
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Unique Identifier:
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D050051
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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