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TRIMETHOPRIM
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DeCS
Descriptor
English
:
Trimethoprim
Descriptor
Spanish
:
Trimetoprim
Descriptor
Portuguese
:
Trimetoprima
Tree Number:
D03.383.742.906
Definition
English
:
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to
PYRIMETHAMINE
. The interference with
folic acid
metabolism
may cause a
depression
of
hematopoiesis
. It is potentiated by
SULFONAMIDES
and the
TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION
is the form most often used. It is sometimes used alone as an antimalarial.
TRIMETHOPRIM RESISTANCE
has been reported.
Indexing Annotation
English
:
consider
TRIMETHOPRIM RESISTANCE
for nonsusceptibility of
bacteria
Pharmacological Action:
Anti-Infective Agents, Urinary
Antimalarials
Folic Acid Antagonists
See Related
English
:
Trimethoprim Resistance
History Note
English
:
74(72)
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
14697
Unique Identifier:
D014295
Occurrence in VHL
:
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