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TRIMETREXATE
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DeCS
Descriptor
English
:
Trimetrexate
Descriptor
Spanish
:
Trimetrexato
Descriptor
Portuguese
:
Trimetrexato
Tree Number:
D03.438.786.925
Definition
English
:
A nonclassical
folic acid
inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for
efficacy
as an antineoplastic agent and as an antiparasitic agent against
PNEUMOCYSTIS
PNEUMONIA
in AIDS
patients
. Myelosuppression is its dose-limiting toxic effect.
Pharmacological Action:
Antifungal Agents
Antimetabolites, Antineoplastic
Folic Acid Antagonists
History Note
English
:
92; was TRIMETREXATE (NM) 1979-91
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
standards
toxicity
therapeutic use
urine
Record Number:
29766
Unique Identifier:
D016597
Occurrence in VHL
:
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