Search on: TYPE I RESTRICTION ENZYMES 
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Descriptor English:   Deoxyribonucleases, Type I Site-Specific 
Descriptor Spanish:   Desoxirribonucleasas de Localización Especificada Tipo I 
Descriptor Portuguese:   Desoxirribonucleases de Sítio Específico do Tipo I 
Synonyms English:   DNA Restriction Enzymes, Type I
Restriction Endonucleases, Type I
Type I Restriction Enzymes
DNase, Site-Specific, Type I  
Tree Number:   D08.811.150.280.250
D08.811.277.352.335.350.300.250
D08.811.277.352.355.325.300.250
Definition English:   Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3. 
Indexing Annotation English:   DF: DNASE SS I
History Note English:   89 
Allowable Qualifiers English:  
administration & dosage adverse effects
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications drug effects
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
ultrastructure urine
Record Number:   23602 
Unique Identifier:   D015253 

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