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TAU PROTEINS
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DeCS
Descriptor
English
:
tau Proteins
Descriptor
Spanish
:
Proteínas tau
Descriptor
Portuguese
:
Proteínas tau
Tree Number:
D12.776.220.600.450.510
D12.776.641.560.510
Definition
English
:
Microtubule-associated
proteins
that are mainly expressed in
neurons
.
Tau proteins
constitute several isoforms and play an important
role
in the assembly of
tubulin
monomers into
microtubules
and in maintaining the
cytoskeleton
and
axonal transport
. Aggregation of specific sets of
tau proteins
in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES;
NEUROPIL
THREADS) in numerous neurodegenerative disorders (ALZHEIMER
DISEASE
; TAUOPATHIES).
See Related
English
:
Tauopathies
History Note
English
:
1992; use TAU (NM) 1977-91
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
30290
Unique Identifier:
D016875
Occurrence in VHL
:
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