Search on: DOWN-REGULATION 
Descriptors Found: 1
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Descriptor English:   Down-Regulation 
Descriptor Spanish:   Regulación hacia Abajo 
Descriptor Portuguese:   Regulação para Baixo 
Synonyms English:   Receptor Down-Regulation  
Tree Number:   G05.315.200
G06.184.320
G07.621.487.500
G12.307
Definition English:   A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. 
Indexing Annotation English:   DF: DOWN REG
See Related English:   Feedback, Biochemical
Up-Regulation
 
History Note English:   2002 (1990) 
Allowable Qualifiers English:  
drug effects ethics
genetics immunology
physiology radiation effects
Record Number:   24611 
Unique Identifier:   D015536 

Occurrence in VHL:
 

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