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KALLIKREIN
Descriptors Found:
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DeCS
Descriptor
English
:
Kallikreins
Descriptor
Spanish
:
Calicreínas
Descriptor
Portuguese
:
Calicreínas
Synonyms
English
:
Kininogenase
Kallikrein
Tree Number:
D08.811.277.656.300.760.442
D12.776.124.125.597
D23.119.597
Definition
English
:
Proteolytic
enzymes
from the
serine
endopeptidase
family
found in normal
blood
and
urine
. Specifically,
Kallikreins
are potent vasodilators and hypotensives and increase vascular
permeability
and
affect
smooth muscle. They act as
infertility
agents in
men
. Three
forms
are recognized,
PLASMA KALLIKREIN
(EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and
PROSTATE-SPECIFIC ANTIGEN
(EC 3.4.21.77).
Indexing Annotation
English
:
/antag permitted but consider KALLIKREIN-TRYPSIN INACTIVATOR
Pharmacological Action:
Coagulants
Fertility Agents, Male
See Related
English
:
Coagulants
History Note
English
:
2000(1963)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
23326
Unique Identifier:
D007610
Occurrence in VHL
:
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