Search on:
KARYOPHERIN-BETA
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
beta Karyopherins
Descriptor
Spanish
:
beta Carioferinas
Descriptor
Portuguese
:
beta Carioferinas
Synonyms
English
:
Karyopherin-beta
Tree Number:
D12.776.157.530.750.500.249
D12.776.543.585.750.500.249
D12.776.660.502.500
Definition
English
:
Nucleocytoplasmic transport molecules that bind to
ALPHA KARYOPHERINS
in the
CYTOSOL
and are involved in transport of molecules through the
NUCLEAR PORE
COMPLEX. Once inside the
CELL NUCLEUS
beta karyopherins
interact with
RAN GTP-BINDING PROTEIN
and dissociate from
alpha karyopherins
.
Beta karyopherins
bound to
RAN GTP-BINDING PROTEIN
are then re-transported to the
cytoplasm
where
hydrolysis
of the GTP of
RAN GTP-BINDING PROTEIN
causes release of karyopherin beta.
History Note
English
:
2002; use BETA KARYOPHERINS (NM) 1995-2001; for IMPORTIN-BETA use KARYOPHERINS (NM) 1995-2001
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
36193
Unique Identifier:
D028961
Occurrence in VHL
:
Similar:
DeCS
SciELO
LILACS
LIS