Search on: KARYOPHERINS 
Descriptors Found: 1
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Descriptor English:   Karyopherins 
Descriptor Spanish:   Carioferinas 
Descriptor Portuguese:   Carioferinas 
Synonyms English:   Importins  
Tree Number:   D12.776.157.530.750.500
D12.776.543.585.750.500
D12.776.660.502
Definition English:   A family of proteins involved in NUCLEOCYTOPLASMIC TRANSPORT. Karyopherins are heteromeric molecules composed two major types of components, ALPHA KARYOPHERINS and BETA KARYOPHERINS, that function together to transport molecules through the NUCLEAR PORE COMPLEX. Several other proteins such as RAN GTP BINDING PROTEIN and CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN bind to karyopherins and participate in the transport process. 
See Related English:   Active Transport, Cell Nucleus
 
History Note English:   2002; use KARYOPHERINS (NM) 1995-2001 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
drug effects deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use ultrastructure
urine  
Record Number:   36191 
Unique Identifier:   D028884 

Occurrence in VHL:
 

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