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KININOGENS
Descriptors Found:
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DeCS
Descriptor
English
:
Kininogens
Descriptor
Spanish
:
Quininógenos
Descriptor
Portuguese
:
Cininogênios
Synonyms
English
:
Cystatins, Kininogen
Tree Number:
D12.644.276.812.654
D12.776.124.125.635
D12.776.467.812.654
D12.776.811.420
D23.119.630
D23.469.050.375.425
D23.529.812.654
Definition
English
:
Endogenous
peptides
present in most
body fluids
. Certain
enzymes
convert them to active
KININS
which are involved in
inflammation
,
blood
clotting, complement reactions, etc.
Kininogens
belong to the cystatin superfamily. They are
cysteine proteinase inhibitors
. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by
plasma kallikrein
to produce
BRADYKININ
. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce
KALLIDIN.
Indexing Annotation
English
:
cysteine proteinase inhib; /drug eff /physiol permitted
Pharmacological Action:
Cysteine Proteinase Inhibitors
History Note
English
:
74(72)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
urine
Record Number:
28118
Unique Identifier:
D007704
Occurrence in VHL
:
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