Search on: QUININE 
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Descriptor English:   Quinine 
Descriptor Spanish:   Quinina 
Descriptor Portuguese:   Quinina 
Tree Number:   D03.132.206.719
D03.438.810.762
D03.605.687.762
Definition English:   An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. 
Indexing Annotation English:   /biosyn permitted if by plant
Pharmacological Action:   Analgesics, Non-Narcotic
Antimalarials
Muscle Relaxants, Central
 
Allowable Qualifiers English:  
analogs & derivatives administration & dosage
adverse effects agonists
antagonists & inhibitors analysis
biosynthesis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use urine
Record Number:   12240 
Unique Identifier:   D011803 

Occurrence in VHL:
 

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