Search on: UBIQUITIN 
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Descriptor English:   Ubiquitin 
Descriptor Spanish:   Ubiquitina 
Descriptor Portuguese:   Ubiquitina 
Tree Number:   D12.776.947.500
Definition English:   A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell. 
Indexing Annotation English:   UBIQUITINS
History Note English:   2002; use UBIQUITINS (1985-2001) 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
drug effects deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use ultrastructure
urine  
Record Number:   36260 
Unique Identifier:   D025801 

Occurrence in VHL:
 

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