Search on: ORTHO,PARA-DDD 
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Descriptor English:   Mitotane 
Descriptor Spanish:   Mitotano 
Descriptor Portuguese:   Mitotano 
Synonyms English:   o,p-DDD
ortho,para-DDD  
Tree Number:   D02.455.526.439.681
Definition English:   A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. 
Indexing Annotation English:   TN 111 for eff on insects
Pharmacological Action:   Antineoplastic Agents, Hormonal
 
History Note English:   73 
Allowable Qualifiers English:  
analogs & derivatives administration & dosage
adverse effects agonists
antagonists & inhibitors analysis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
diagnostic use economics
history immunology
isolation & purification metabolism
pharmacology pharmacokinetics
poisoning radiation effects
supply & distribution standards
toxicity therapeutic use
urine  
Record Number:   9129 
Unique Identifier:   D008939 

Occurrence in VHL: 		 

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