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INSULIN
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DeCS
Descriptor
English
:
Insulin
Descriptor
Spanish
:
Insulina
Descriptor
Portuguese
:
Insulina
Tree Number:
D06.472.699.587.740.625
D12.644.548.586.740.625
Definition
English
:
A 51-amino acid pancreatic hormone that plays a major
role
in the regulation of
glucose
metabolism
, directly by suppressing endogenous
glucose
production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing
GLUCAGON
secretion and
LIPOLYSIS
. Native
insulin
is a globular protein comprised of a zinc-coordinated hexamer. Each
insulin
monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds.
Insulin
is used as a drug to
control
insulin-dependent
diabetes mellitus
(DIABETES MELLITUS, TYPE 1).
Indexing Annotation
English
:
/blood: consider also HYPERINSULINEMIA (excessively high
blood
insulin
levels) but do not confuse with
HYPERINSULINISM
(excessive secretion of
insulin
by pancreas);
/immunology
: consider also
INSULIN ANTIBODIES
; precursor =
PROINSULIN
;
INSULIN INFUSION SYSTEMS
is available
Pharmacological Action:
Hypoglycemic Agents
Entry Combination - descr/qualif
English
:
Insulin
/
antagonists & inhibitors
use
Insulin Antagonists
See Related
English
:
Hyperinsulinism
Nonsuppressible Insulin-Like Activity
Proinsulin
Receptor, Insulin
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
urine
Record Number:
7500
Unique Identifier:
D007328
Occurrence in VHL
:
Similar:
DeCS
SciELO
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