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DeCS
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Descriptor English:
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Prions
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Descriptor Spanish:
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Priones
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Descriptor Portuguese:
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Príons
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Synonyms English:
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Mink Encephalopathy Virus
Prion Proteins
PrP Proteins
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Tree Number:
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D12.776.785
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Definition English:
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Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL. |
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Indexing Annotation English:
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/pathogen permitted
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History Note English:
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86; MINK ENCEPHALOPATHY VIRUS was heading 1991-92, was see under VERTEBRATE VIRUSES, UNCLASSIFIED (now VIRUSES, UNCLASSIFIED) 1975-90; TRANSMISSIBLE ENCEPHALOPATHY VIRUS OF MINK was see MINK ENCEPHALOPATHY VIRUS 1975-92
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Allowable Qualifiers English:
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Record Number:
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19524
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Unique Identifier:
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D011328
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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