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THYROXINE
Descriptors Found:
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DeCS
Descriptor
English
:
Thyroxine
Descriptor
Spanish
:
Tiroxina
Descriptor
Portuguese
:
Tireoxina
Synonyms
English
:
Levothyroxine
L-Thyroxine
T4 Thyroid Hormone
Tree Number:
D06.472.931.812
D12.125.072.050.767
Definition
English
:
The major hormone derived from the
thyroid gland
.
Thyroxine
is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the
THYROGLOBULIN
.
Thyroxine
is released from
thyroglobulin
by proteolysis and secreted into the
blood
.
Thyroxine
is peripherally deiodinated to form
TRIIODOTHYRONINE
which exerts a broad spectrum of stimulatory effects on cell
metabolism.
Indexing Annotation
English
:
/blood: consider also
HYPERTHYROXINEMIA
See Related
English
:
Hyperthyroxinemia
Receptors, Thyroid Hormone
History Note
English
:
1965; use THYROXIN 1963-1964; for LEVOTHYROXINE use LEVOTHYROXINE 1991-2001, use THYROXINE 1966-1990
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
urine
Record Number:
14360
Unique Identifier:
D013974
Occurrence in VHL
:
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