Search on:
CYP1A2
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Cytochrome P-450 CYP1A2
Descriptor
Spanish
:
Citocromo P-450 CYP1A2
Descriptor
Portuguese
:
Citocromo P-450 CYP1A2
Synonyms
English
:
CYP1A2
Phenacetin O-Dealkylase
Tree Number:
D08.244.453.040.777
D08.811.682.690.708.170.040.443
D12.776.422.220.453.040.555
Definition
English
:
A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic
xenobiotics
in the
liver
of human and several animal species. This enzyme is of significant clinical interest due to the large number of
drug interactions
associated with its induction and its
metabolism
of
THEOPHYLLINE
.
Caffeine
is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette
smoking
, charbroiled
meat
, cruciferous
vegetables
, and a number of drugs including
phenytoin
,
phenobarbital
, and
omeprazole.
Indexing Annotation
English
:
do not confuse with other cytochrome P-450 CYP's
History Note
English
:
97; was PHENACETIN O-DEALKYLASE (NM) 1976-96
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
33009
Unique Identifier:
D019388
Occurrence in VHL
:
Similar:
DeCS
SciELO
LILACS
LIS