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COCAINE
Descriptors Found:
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DeCS
Descriptor
English
:
Cocaine
Descriptor
Spanish
:
Cocaína
Descriptor
Portuguese
:
Cocaína
Tree Number:
D02.145.074.722.388
D03.132.889.354
D03.605.869.388
D04.075.080.875.099.722.388
Definition
English
:
An alkaloid ester extracted from the leaves of
plants
including
coca
. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the
eye
,
ear
,
nose
, and throat. It also has powerful
central nervous system
effects
similar
to the
amphetamines
and is a drug of abuse.
Cocaine
, like
amphetamines
, acts by multiple mechanisms on
brain
catecholaminergic
neurons
; the mechanism of its reinforcing effects is thought to involve inhibition of
dopamine
uptake.
Indexing Annotation
English
:
cocaine derivatives =
COCAINE
/analogs;
CRACK COCAINE
is available;
cocaine
addiction =
COCAINE-RELATED DISORDERS
Pharmacological Action:
Anesthetics, Local
Dopamine Uptake Inhibitors
Vasoconstrictor Agents
History Note
English
:
COCAINE DERIVATIVES was see under COCAINE 1975-77; was see under TROPANES 1969-74
Allowable Qualifiers
English
:
analogs & derivatives
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
urine
Record Number:
3070
Unique Identifier:
D003042
Occurrence in VHL
:
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