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IMMUNOGLOBULINS
Descriptors Found:
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DeCS
Descriptor
English
:
Immunoglobulins
Descriptor
Spanish
:
Inmunoglobulinas
Descriptor
Portuguese
:
Imunoglobulinas
Synonyms
English
:
Globulins, Immune
Immune Globulins
Tree Number:
D12.776.124.486.485
D12.776.124.790.651
D12.776.377.715.548
Definition
English
:
Multi-subunit
proteins
which function in
IMMUNITY
. They are produced by B
LYMPHOCYTES
from the IMMUNOGLOBULIN
GENES
. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two
light
chains (IMMUNOGLOBULIN
LIGHT
CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric
forms
, and transmembrane
forms
(B-CELL ANTIGEN RECEPTORS) or secreted
forms
(ANTIBODIES). They are divided by the
amino acid sequence
of their heavy chains into five classes (IMMUNOGLOBULIN A;
IMMUNOGLOBULIN D
;
IMMUNOGLOBULIN E
;
IMMUNOGLOBULIN G
; IMMUNOGLOBULIN M) and various subclasses.
Indexing Annotation
English
:
general: prefer specifics; /admin: consider also
IMMUNOGLOBULINS
, INTRAVENOUS; /defic permitted but consider also
IMMUNOLOGIC DEFICIENCY SYNDROMES
; /ther use: consider also IMMUNOGLOBULIN THERAPY see
IMMUNIZATION
, PASSIVE; allotypes =
IMMUNOGLOBULIN ALLOTYPES
or specifics
Pharmacological Action:
Immunologic Factors
See Related
English
:
Immunity
Paraproteinemias
History Note
English
:
72(70); IMMUNE SERUM GLOBULIN was heading 1965; GLOBULINS, IMMUNE & IMMUNE GLOBULINS were see IMMUNOGLOBULINS, INTRAVENOUS 1992-93
Allowable Qualifiers
English
:
administration & dosage
adverse effects
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
poisoning
radiation effects
toxicity
therapeutic use
ultrastructure
urine
Record Number:
22210
Unique Identifier:
D007136
Occurrence in VHL
:
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