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SIRTUINS
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DeCS
Descriptor
English
:
Sirtuins
Descriptor
Spanish
:
Sirtuinas
Descriptor
Portuguese
:
Sirtuinas
Synonyms
English
:
SIR2-Like Proteins
Tree Number:
D08.811.277.087.831
D08.811.913.400.725.115.845
Definition
English
:
A homologous
family
of
proteins
that includes the NAD-dependent protein deacetylases which deacetylate
proteins
by catalyzing the formation of
O-acetyl-ADP-ribose
from the ADP-RIBOSE moiety (of NAD) and the acetyl group that is being removed from the protein. Sir2p, from
Saccharomyces cerevisiae
, is the founding member and the
family
includes other homologs (HSTs - homologs of Sir Two). Some
HISTONE DEACETYLASES
(the Sir2-like HDACs) belong to this
family
of
proteins.
Indexing Annotation
English
:
note specific
sirtuins
in SCR
See Related
English
:
Histone Deacetylases
Silent Information Regulator Proteins, Saccharomyces cerevisiae
History Note
English
:
2003
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
37322
Unique Identifier:
D037761
Occurrence in VHL
:
Similar:
DeCS
SciELO
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