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TRANSDUCIN
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DeCS
Descriptor
English
:
Transducin
Descriptor
Spanish
:
Transducina
Descriptor
Portuguese
:
Transducina
Synonyms
English
:
alpha-Transducin
beta-Transducin
gamma-Transducin
G-Protein, Inhibitory Gt
Gt, Transducin G-Protein
Tree Number:
D08.811.277.040.330.300.200.800
D12.644.360.375.940
D12.776.157.325.332.940
D12.776.476.375.940
D12.776.543.325.800
Definition
English
:
A heterotrimeric GTP-binding protein that mediates the
light
activation signal from photolyzed
rhodopsin
to
cyclic GMP
phosphodiesterase and is pivotal in the visual excitation process. Activation of
rhodopsin
on the outer membrane of rod and cone
cells
causes GTP to bind to
transducin
followed by dissociation of the alpha subunit-GTP complex from the beta/gamma subunits of
transducin
. The alpha subunit-GTP complex activates the
cyclic GMP
phosphodiesterase which catalyzes the
hydrolysis
of
cyclic GMP
to 5'-GMP. This leads to closure of the
sodium
and
calcium channels
and therefore hyperpolarization of the rod
cells
. EC 3.6.1.-.
Indexing Annotation
English
:
alpha, beta and gamma transducins refer to its subunits
History Note
English
:
89
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
23850
Unique Identifier:
D015293
Occurrence in VHL
:
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